MersV1, Main, Exploration, bibRecord, 003F87

Class I HLA-restricted cytotoxic T lymphocyte responses against malaria-elucidation on the basis of HLA peptide binding motifs

Identifieur interne : 003F87 ( Main/Exploration ); précédent : 003F86; suivant : 003F88

Class I HLA-restricted cytotoxic T lymphocyte responses against malaria-elucidation on the basis of HLA peptide binding motifs

Auteurs : Denise L. Doolan [États-Unis] ; Benjamin Wizel [États-Unis] ; Stephen L. Hoffman [États-Unis]

Source :

Immunologic Research [ 0257-277X ] ; 1996-12-01.

RBID : ISTEX:98C2CD10C58660BE0517A46F9560A42083C697B1

English descriptors

Abstract

Abstract: In animal models, CD8+ T cells are a critical effector mechanism in the protective immunity against malaria. Conventional approaches to the development of many vaccines, including those against malaria, have however proved inadequate. In particular, an alternative approach is needed for the development of vaccines designed to induce a cellular immune response mediated by CD8+ T cells. Advances in the field of molecular immunology during the past decade have provided an insight into the presentation of peptides by MHC class I molecules and their recognition by CD8+ T cells. These studies have provided a conceptual basis for the development of efficacious parasitic and viral vaccines. By a combination of immunochemical and cellular immunologic analyses based on specific peptide binding motifs, a subunit malaria vaccine that includes CD8+ T cell epitopes restricted by the most common class I HLA alleles, including HLA-A2, can now be constructed.

Url:

https://api.istex.fr/ark:/67375/1BB-CNQNMZFQ-Z/fulltext.pdf

DOI: 10.1007/BF02935313

Affiliations:

États-Unis

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Le document en format XML

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</author>
<author><name sortKey="Wizel, Benjamin" sort="Wizel, Benjamin" uniqKey="Wizel B" first="Benjamin" last="Wizel">Benjamin Wizel</name>
</author>
<author><name sortKey="Hoffman, Stephen L" sort="Hoffman, Stephen L" uniqKey="Hoffman S" first="Stephen L." last="Hoffman">Stephen L. Hoffman</name>
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<series><title level="j">Immunologic Research</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cytotoxic T lymphocytes</term>
<term>HLA peptide binding motifs</term>
<term>HLA-A2</term>
<term>HLA-restricted cytotoxic T lymphocytes</term>
<term>Malaria</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Acad</term>
<term>Adoptive transfer</term>
<term>Allele</term>
<term>Amino</term>
<term>Amino acids</term>
<term>Anchor residues</term>
<term>Antigen</term>
<term>Antigen processing</term>
<term>Antigenic</term>
<term>Antigenic protein</term>
<term>Beaudoin</term>
<term>Berghei</term>
<term>Binding affinity</term>
<term>Binding motif</term>
<term>Binding motifs</term>
<term>Binding peptides</term>
<term>Bold type</term>
<term>Bull world health organ</term>
<term>Cell activation</term>
<term>Cell epitopes</term>
<term>Cell recognition</term>
<term>Cell responses</term>
<term>Cell surface</term>
<term>Circumsporozoite</term>
<term>Circumsporozoite protein</term>
<term>Clone</term>
<term>Cytolytic</term>
<term>Cytolytic activity</term>
<term>Cytotoxic</term>
<term>Doolan</term>
<term>Effector</term>
<term>Effector cells</term>
<term>Epitope</term>
<term>Falciparum</term>
<term>Falciparum malaria</term>
<term>Groove</term>
<term>Heavy chain</term>
<term>Hepatitis</term>
<term>Hepatocyte</term>
<term>Hepatocytes</term>
<term>High affinity</term>
<term>Histocompatibility</term>
<term>Hoffman</term>
<term>Hollingdale</term>
<term>Houghten</term>
<term>Human cytotoxic</term>
<term>Human immunodeficiency virus</term>
<term>Immune</term>
<term>Immune response</term>
<term>Immunization</term>
<term>Immunogenic</term>
<term>Immunol</term>
<term>Influenza virus</term>
<term>Leucine</term>
<term>Lmmunol</term>
<term>Lymphocyte</term>
<term>Lymphocyte responses</term>
<term>Major histocompatibility</term>
<term>Malaria</term>
<term>Malaria sporozoites</term>
<term>Mcmichael</term>
<term>Molecule</term>
<term>Natl</term>
<term>Nonamer</term>
<term>Nussenzweig</term>
<term>Parasite</term>
<term>Peptide</term>
<term>Peptide antigens</term>
<term>Peptide binding</term>
<term>Peptide binding groove</term>
<term>Peptide binding motifs</term>
<term>Peptides binding</term>
<term>Pfcsp</term>
<term>Pfssp2</term>
<term>Plasmodium</term>
<term>Plasmodium berghei</term>
<term>Plasmodium falciparum</term>
<term>Plasmodium falciparum circumsporozoite protein</term>
<term>Plasmodium falciparum sporozoite surface protein</term>
<term>Plasmodium yoelii</term>
<term>Polymorphism</term>
<term>Precursor</term>
<term>Proc</term>
<term>Proc natl acad</term>
<term>Protective immunity</term>
<term>Rammensee</term>
<term>Recombinant</term>
<term>Residue</term>
<term>Sedegah</term>
<term>Sette</term>
<term>Severe malaria</term>
<term>Sporozoite</term>
<term>Sporozoite vaccine</term>
<term>Starp</term>
<term>Subtypes</term>
<term>Synthetic peptides</term>
<term>Target cells</term>
<term>Tissue antigens</term>
<term>Vaccine</term>
<term>Vaccine development</term>
<term>Vaccinia</term>
<term>Viral</term>
<term>Viral peptides</term>
<term>Weiss</term>
<term>Wizel</term>
<term>Yoelii</term>
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<front><div type="abstract" xml:lang="en">Abstract: In animal models, CD8+ T cells are a critical effector mechanism in the protective immunity against malaria. Conventional approaches to the development of many vaccines, including those against malaria, have however proved inadequate. In particular, an alternative approach is needed for the development of vaccines designed to induce a cellular immune response mediated by CD8+ T cells. Advances in the field of molecular immunology during the past decade have provided an insight into the presentation of peptides by MHC class I molecules and their recognition by CD8+ T cells. These studies have provided a conceptual basis for the development of efficacious parasitic and viral vaccines. By a combination of immunochemical and cellular immunologic analyses based on specific peptide binding motifs, a subunit malaria vaccine that includes CD8+ T cell epitopes restricted by the most common class I HLA alleles, including HLA-A2, can now be constructed.</div>
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<affiliations><list><country><li>États-Unis</li>
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<name sortKey="Hoffman, Stephen L" sort="Hoffman, Stephen L" uniqKey="Hoffman S" first="Stephen L." last="Hoffman">Stephen L. Hoffman</name>
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Class I HLA-restricted cytotoxic T lymphocyte responses against malaria-elucidation on the basis of HLA peptide binding motifs

Class I HLA-restricted cytotoxic T lymphocyte responses against malaria-elucidation on the basis of HLA peptide binding motifs

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri